Purchase of an HPLC

这项建议是为了更换1991年7月购买的现有高压液相色谱仪。目前的HPLC已被广泛使用，但其服务合同早已到期，需要频繁和昂贵的维修以维持其正常运行。它连接到一个运行在Windows 95/98上的数据采集系统。目前的HPLC几乎不间断地使用，但由于维护和维修而经常离线。此外，数据采集系统经常崩溃，需要IT专家进行干预。目前的申请是与发现基金申请同时提出的，该申请描述了我们最近在研究中取得的突破，该突破导致了高价值分子的生物生产，如中性药物和药物前体分子。所要求的高效液相色谱将专门用于支持这项研究，并且将是承担这项研究所需的唯一分析设备。我们需要一个基本的HPLC与2个检测器，和一个最新的采集系统。没有可靠、有效的高效液相色谱法，本研究无法开展。

This proposal is for the replacement of an existing high pressure liquid chromatograph (HPLC) that was purchased in July 1991. The current HPLC has been extensively used but its service contract has long expired, necessitating frequent and expensive service to maintain it in a functioning condition. It is connected to a data acquisition system that runs on Windows 95/98. The current HPLC has been used almost non-stop, but is often off-line due to maintenance and repairs. Moreover, the data acquisition system regularly crashes, requiring intervention by an IT specialist. The present request is being made in parallel with a Discovery Grant application that describes a recent breakthrough in our research leading to the enhanced bioproduction of high value molecules, such as neutraceuticals and drug precursor molecules. The requested HPLC would be dedicated to support this research, and would be the sole item of analytical equipment required to undertake it. We are requesting a basic HPLC with 2 detectors, and an up to date acquisition system. Without a reliable, working HPLC, the research could not be undertaken.