Reversing the biomechanical dysregulation of cancer cell signalling to improve targeted therapies

抗癌药物的有限成功取决于许多因素，包括肿瘤的物理特性(僵硬)。特别是，肿瘤是软的还是硬的会影响它对治疗的反应。将经典生物学与工程学相结合，生成模拟肿瘤的3D模型，以及尖端成像技术，我们将确定如何将肿瘤的物理属性与已经批准的抗癌药物一起靶向，以改善治疗和患者结果。

The limited success of cancer drugs is dependent on many factors including the physical properties (stiffness) of a tumour. In particular whether a tumour is soft or stiff affects how it responds to treatment. Combining classical biology with engineering to generate 3D models that mimic tumours, along with cutting-edge imaging technology, we will determine how we can target the physical properties of tumours together with already approved cancer drugs to improve treatment and patient outcome.