The role of apoptosis in pathogenesis and immunology of Salmonella infections

沙门氏菌在发达国家和发展中国家都是重要的人类病原体。最严重的沙门氏菌病——伤寒，由于抗生素耐药性的增加，正变得越来越难以治疗。此外，目前的疫苗只能提供短期保护。本提案中的研究旨在回答有关伤寒免疫的重要问题，包括这种免疫是如何引起的，以及疾病病理的直接和间接原因。本项目的重点是诱导宿主细胞凋亡，这是许多细菌和病毒共有的重要毒力机制。这项研究将直接应用于人类伤寒，并可能导致新的治疗方法和改进的伤寒疫苗。

Salmonellae are important human pathogens in developed and developing countries. The most severe salmonella disease, typhoid fever, is becoming more difficult to treat because of increasing antibiotic resistance. In addition, current vaccines only provide short-term protection. The studies in this proposal are designed to answer important questions about immunity against typhoid fever, including how this immunity is provoked, and the direct and indirect causes of pathology in the disease. The focus of this project is the induction of host cell apoptosis, an important virulence mechanism shared by many bacteria and viruses. The research will have direct application to human typhoid and may lead to novel therapies and improved vaccines for typhoid fever.