Role of autotransporter proteins in uropathogenic E. coli infections
Role of autotransporter proteins in uropathogenic E. coli infections
批准号:
nhmrc : 1042651
负责人:
Prof Mark Schembri
金额:
$40.75万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31
中文摘要
尿路感染是人类最常见的传染病之一。尿路致病性大肠杆菌(UPEC)是尿路感染的主要原因,它利用一系列的黏附机制定植于尿路。在这个项目中,我们将描述一类重要的UPEC黏附因子--自身转运蛋白的功能和分泌方式。这项工作可能为预防尿路感染提供新的方法,鉴于UPEC对抗生素的耐药性迅速增加,这是一种迫切需要。
英文摘要
Urinary tract infections (UTI) are among the most common infectious diseases of humans. Uropathogenic E. coli (UPEC), the primary cause of UTI, utilize a range of adherence mechanisms to colonize the urinary tract. In this project we will characterise the function and mode of secretion for one important class of UPEC adherence factors – autotransporter proteins. This work may inform new approaches to prevent UTI, an urgent need given the rapid increase in resistance to antibiotics among UPEC.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Untangling the matrix of bacterial biofilms
-
批准号:DP230101930
-
项目类别:Discovery Projects
-
资助金额:$33.22万
-
财政年份:2023
-
负责人:Prof Mark Schembri
-
依托单位:
The dual-edged sword of zinc as an innate immune antimicrobial weapon against uropathogenic E. coli
-
批准号:nhmrc : GNT1144967
-
项目类别:Project Grants
-
资助金额:$78.44万
-
财政年份:2018
-
负责人:Prof Mark Schembri
-
依托单位:
The dual-edged sword of zinc as an innate immune antimicrobial weapon against uropathogenic E. coli
-
批准号:nhmrc : 1144967
-
项目类别:Project Grants
-
资助金额:$53.04万
-
财政年份:2018
-
负责人:Prof Mark Schembri
-
依托单位:
Membrane-active antibiotics against multi-drug resistant Gram negative bacteria
-
批准号:nhmrc : 1106590
-
项目类别:Project Grants
-
资助金额:$64.88万
-
财政年份:2016
-
负责人:Prof Mark Schembri
-
依托单位:
Halting the spread multidrug resistant uropathogenic E. coli
-
批准号:nhmrc : GNT1106930
-
项目类别:Research Fellowships
-
资助金额:$68.8万
-
财政年份:2016
-
负责人:Prof Mark Schembri
-
依托单位:
Halting the spread multidrug resistant uropathogenic E. coli
-
批准号:nhmrc : 1106930
-
项目类别:Research Fellowships
-
资助金额:$47.43万
-
财政年份:2016
-
负责人:Prof Mark Schembri
-
依托单位:
Membrane-active antibiotics against multi-drug resistant Gram negative bacteria
-
批准号:nhmrc : GNT1106590
-
项目类别:Project Grants
-
资助金额:$94.23万
-
财政年份:2016
-
负责人:Prof Mark Schembri
-
依托单位:
The current multidrug resistant Escherichia coli pandemic: exploring novel therapies against the predominant culprit E. coli ST131.
-
批准号:nhmrc : 1069370
-
项目类别:Project Grants
-
资助金额:$34.16万
-
财政年份:2014
-
负责人:Prof Mark Schembri
-
依托单位:
How bacteria cause disease in the urinary tract
-
批准号:FT100100662
-
项目类别:ARC Future Fellowships
-
资助金额:$57.36万
-
财政年份:2011
-
负责人:Prof Mark Schembri
-
依托单位:
Autotransporter proteins of enterohemorrhagic Escherichia coli O157:H7
-
批准号:DP1097032
-
项目类别:Discovery Projects
-
资助金额:$20.9万
-
财政年份:2010
-
负责人:Prof Mark Schembri
-
依托单位:
Adhesins of uropathogenic Escherichia coli
-
批准号:nhmrc : 631654
-
项目类别:NHMRC Project Grants
-
资助金额:$27.05万
-
财政年份:2010
-
负责人:Prof Mark Schembri
-
依托单位:
Disulfide catalysis and protein folding in bacterial virulence
-
批准号:DP1096395
-
项目类别:Discovery Projects
-
资助金额:$20.9万
-
财政年份:2010
-
负责人:Prof Mark Schembri
-
依托单位:
Molecular basis of asymptomatic colonization of the human urinary tract
-
批准号:nhmrc : 569676
-
项目类别:NHMRC Project Grants
-
资助金额:$30.8万
-
财政年份:2009
-
负责人:Prof Mark Schembri
-
依托单位:
Urinary tract E. coli: the good guys versus the bad guys
-
批准号:nhmrc : 401714
-
项目类别:NHMRC Project Grants
-
资助金额:$19.75万
-
财政年份:2007
-
负责人:Prof Mark Schembri
-
依托单位:
Safety in numbers: Bacterial aggregation and adaptation to oxidative stress
-
批准号:DP0666852
-
项目类别:Discovery Projects
-
资助金额:$14.18万
-
财政年份:2006
-
负责人:Prof Mark Schembri
-
依托单位:
Autotransporter proteins of Escherichia coli
-
批准号:DP0557615
-
项目类别:Discovery Projects
-
资助金额:$15.96万
-
财政年份:2005
-
负责人:Prof Mark Schembri
-
依托单位:
Coordinate expression of virulence factors in pathogenic Escherichia coli
-
批准号:nhmrc : 301163
-
项目类别:NHMRC Project Grants
-
资助金额:$15.95万
-
财政年份:2004
-
负责人:Prof Mark Schembri
-
依托单位:
国内基金
海外基金
百日咳博德特氏菌血清抗性蛋白BrkA跨膜结构域的晶体学研究
-
批准号:30970569
-
项目类别:面上项目
-
资助金额:32.0万元
-
批准年份:2009
-
负责人:翟宇佳
-
依托单位: