Role of epigenomic changes in conferring hyperglycemic memory

I型糖尿病的主要负担仍然是其血管并发症，包括糖尿病加速的动脉粥样硬化。尽管改善了葡萄糖控制，但糖尿病个体由于先前血糖控制不良而发展出并发症。虽然这些糖尿病并发症的发展和进展与平均葡萄糖水平密切相关，但最近的研究表明，即使在治疗使葡萄糖水平恢复正常后，早期暴露于高水平葡萄糖的有害影响仍持续多年。

The major burden of type I diabetes remains its vascular complications including diabetes-accelerated athersclerosis. Despite improved glucose control, diabetic individuals develop complications as a result of prior poor glycemic control. Although the development and progression of these diabetic complications is strongly associated with mean levels of glucose, recent studies suggest that the deleterious effects of early exposure to high levels of glucose persist for years even after treatment has returned glucose levels towards normal.