THE ROLE OF THE HEPATOCYTE IN EXTRACELLULAR MATRIX INTERACTIONS IN LIVER FIBROGENESIS

本研究的重点是肝脏内的主要细胞肝细胞及其在肝纤维化发展中的作用。肝损伤引起的肝纤维化有一个共同的进展，其特征是肝脏结构的丧失和组织致密纤维带的发展，这种情况称为肝硬化。概述的研究计划的重要性在于，首次确定肝细胞在肝纤维化的发展中具有重要作用。

This study focuses on the main cell within the liver, the hepatocyte, and its role in the development of liver fibrosis. Liver fibrosis arising from liver injury has a common progression characterised by loss of liver structure and the development of dense fibrous bands of tissue in the condition known as cirrhosis. The importance of the outlined research plan is that for the first time the hepatocyte has been identified as having a significant role in the development of liver fibrosis.