Role of Inflammation in Diabetic Cardiomyopathy

糖尿病性心肌病（DiabCM）在糖尿病患者中很常见。它容易导致热失效。其病因尚不清楚，也没有针对糖尿病性心肌病的特殊治疗方法。炎症是组织对代谢损伤的基本反应，发生在糖尿病患者中。这项工作的中心假设是心肌巨噬细胞的炎症有助于DiabCM。这一假设将在动物模型和细胞培养研究中得到验证。

Diabetic cardiomyopathy (DiabCM) is common in people with diabetes. It predisposes to heat failure. Its cause remains unclear and there is no specific treatment for DiabCM. Inflammation is a fundamental tissue response to a metabolic insult and it occur in DiabCM. The central hypothesis in this work is that inflammation through myocardial macrophage cells contributes to DiabCM. This hypothesis will be tested in animal models and also in cell culutre studies.