The Role of Med12, a subunit of RNA polymerase II mediator, in haemopoiesis

在对斑马鱼进行血细胞发育突变的筛选中，我们分离出了一种名为syrah的突变体。导致血液缺陷的突变是在一个名为med12的基因中发现的，该基因编码细胞中RNA转录机制的一个组成部分。为了了解这种突变如何导致血细胞减少，我们将鉴定与med12蛋白相互作用的蛋白质。了解所涉及的途径可能会导致发现人类先天性血液病的新原因。

In a screen of zebrafish for mutations in blood cell development, we isolated a mutant called syrah. The mutation causing the blood defect was identified in a gene called med12, which encodes a component of the RNA transcription machinery in cells. To understand how this mutation causes a reduction in blood cells, we will identify the proteins that interact with the med12 protein. Understanding the pathway involved may lead to the discovery of new causes of human congenital blood diseases.