Role and potential for therapeutic targeting of dysfunction, oxidative stress and altered metabolism in mitochondria in the pathogenesis of COPD

肺气肿是疾病和死亡的主要原因，目前还没有好的治疗方法。它是由吸烟引起的，导致肺部炎症和疾病，但这是如何发生的还不太清楚。细胞呼吸可能会出现缺陷，导致氧化应激、新陈代谢改变和炎症。我们认为这会导致肺气肿。我们将评估肺气肿患者的呼吸、氧化应激和新陈代谢的变化，并看看我们是否可以通过新的潜在治疗方法来逆转这些变化。

Emphysema is a major cause of illness and death and there are no good treatments. It is caused by smoking that induces lung inflammation and disease but how this occurs is not well understood. Cellular respiration can become defective causing oxidative stress, altered metabolism and inflammation. We think that this drives emphysema. We will assess alterations in respiration, oxidative stress and metabolism in emphysema and see if we can reverse these changes with new potential treatments.