The role of reduced phagocytosis in the pathogenesis of Age-related Macular Degeneration

了解导致年龄相关性黄斑变性（AMD）的潜在机制对于我们最终开发新的治疗方法至关重要。我们假设，随着年龄的增长，清除视网膜中积累的碎片的能力有缺陷，这是AMD发展的关键一步。我们将在AMD队列和临床前模型中研究这一假设，在该模型中，我们将测试改善清除碎片能力的干预的功效。

Understanding the underlying mechanisms which lead to age-related macular degeneration (AMD) is critical if we are to ultimately develop novel treatments. We hypothesise that there is a defective ability to remove debris that accumulates in the retina as we age and this is a crucial step in the development of AMD. We will investigate this hypothesis in an AMD cohort and in a pre-clinical model where we will test the efficacy of an intervention that improves the ability to clear debris.