Role of resident endothelial progenitor cells in melanoma vascularisation and progression

黑色素瘤是澳大利亚最常见的癌症之一。它的生长依赖于营养物质和氧气通过血管的适当输送。这需要肿瘤生长时形成新的血管。在这个项目中，我们打算了解在肿瘤中形成的血管的起源，并识别支持它们的干细胞。我们将使用原理验证实验来确定移除这些干细胞是否允许黑色素瘤肿瘤的消退。

Melanoma is one of the most frequent cancers in Australia. Its growth depends on the rpoper delivery of nutrients and oxygen through blood vessels. This requires the formation of new blood vessels as the tumour grows. In this project we intend to understand the origin of the blood vessels that form in tumours and identify the stem cells that support them. We will use proof of principle experiments to determine whether removal of these stem cells allows the regression of melanoma tumours.