The role of secretory antibodies in mucosal homeostasis

这项提案将解决存在于肠道、肺、眼睛和口腔的所有分泌物中的抗体在维持其来源的粘膜(即覆盖的粘膜)组织的健康方面的作用。长期以来，人们一直认为这些抗体可以阻止细菌和其他病原体附着在粘膜组织的表面。我们的初步发现表明，它们在清除黏膜组织衬里下多余的炎性物质方面具有另一个非常重要的作用，以防止免疫系统识别这些物质。这种承认可能会导致当地的严重后果(即。在肠子里)，更远的，例如。会导致糖尿病。因此，我们认为这些抗体对健康至关重要。这项研究可能会对针对宿主组织的免疫反应引起的疾病产生重要的影响，即糖尿病等所谓的自身免疫性疾病。

This proposal will address the role of the antibodies that are present in all secretions from the gut, the lungs, the eye and mouth in maintaining the health of the mucosal (ie mucous covered) tissues from which they originate. It has long been presumed that these antibodies stop bacteria and other pathogens adhering to the surface of mucosal tissues. Our preliminary findings suggest that they have another very important role in removing excess inflammatory material from beneath the lining of the mucosal tissues, to prevent recognition of this material by the immune system. Such recognition could result in serious consequences both locally (ie. in the gut) and more distally eg. in the pnacreas leading to diabetes. As a consequence, we believe that these antibodies are fundamental to health. The research could have important ramifications for diseases resulting from immune responses against host tissues, so-called autoimmune diseases like diabetes.