The role of somatic mutations in CCCTC-binding factor (CTCF) binding sites in cancer

基因组DNA的三维结构在维持人类细胞的稳定性和功能方面起着至关重要的作用。在癌症中，由于控制这一过程的蛋白质突变，这一组织经常受到干扰。该项目将研究DNA中的突变如何可能改变癌症基因组的三维组织，并将确定这些突变与癌症发展和患者预后之间的联系。

The three dimensional organisation of genomic DNA has been recognised to play a crucial role in maintaining the stability and function of human cells. In cancer this organisation is often perturbed as a result of mutations to proteins that govern this process. This project will examine how mutations in the DNA may potentially alter the three dimensional organisation of cancer genomes and will identify links between these mutations with cancer development and patient prognosis.