New developments in organic synthesis

我们的研究计划旨在开发新的策略和新的合成方法和试剂，以高效和选择性地生成碳-碳和碳-杂原子键。复杂的生物活性天然产物或其他与药物相关的分子，包含独特的结构基序，特别令人感兴趣，将使用我们实验室开发的新方法来解决。我们对含氮杂环的合成、有机硼化合物的使用、周环反应(包括电环化、Sigma重排和环加成反应)以及过渡金属催化的反应特别感兴趣。我们定义了方法的范围，并确定了反应的机理。对其他合成有机化学和药物化学问题具有广泛适用性和实用价值的反应和试剂尤其令人感兴趣。我们实验室合成的分子在生物筛选中进行测试，以对抗与癌症或疼痛有关的靶点。该项目不仅在所开发的科学技术方面具有重要意义，而且还为对制药、生物技术和农化行业研究职业感兴趣的学生提供了培训和研究环境。

Our research program is aimed at the development of novel strategies and new synthetic methods and reagents for the efficient and selective generation of carbon-carbon and carbon-heteroatom bonds. Complex biologically active natural products or other pharmaceutically relevant molecules, containing unique structural motifs are of particular interest, and will be tackled using the new methods developed in our laboratories. We are particularly interested in the synthesis of nitrogen heterocycles, the use of organoboron compounds, pericyclic reactions (including electrocyclizations, sigmatropic rearrangements, and cycloadditions), and transition metal catalyzed reactions. We define the scope of the methods and determine the mechanism of the reactions. Reactions and reagents that are of broad applicability and practical benefit to other synthetic organic and medicinal chemistry problems are of particular interest. Molecules synthesized in our laboratories are tested in biological screens, against targets implicated in cancer or pain. This program is significant not only in terms of the science and technology developed, but also provides the training and research environment for students interested in research careers in the pharmaceutical, biotechnology and agrochemical industries.