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The role of thymocyte self-renewal in causing T cell leukaemia

The role of thymocyte self-renewal in causing T cell leukaemia
胸腺细胞自我更新在引起T细胞白血病中的作用
批准号:
nhmrc : 628368
负责人:
A/Pr David Curtis
金额:
$39.11万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31

项目摘要

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中文摘要
翻译
急性白血病治疗后的复发是由于存在能够自我更新的未成熟细胞,这一过程通常仅限于干细胞。通过对患白血病的小鼠的研究,我们已经确定了这些非常罕见的自我更新细胞,它们对标准疗法具有抵抗力。我们可以在白血病发生前几个月鉴定和测量这些细胞。因此,我们将使用这个小鼠模型来了解这些细胞如何自我更新以及它们如何被杀死
英文摘要
Recurrence of acute leukamia after therapy is due to the presence of immature cells that can self-renew, a process that is normally restricted to stem cells. Through the study of mice that develop leukaemia, we have identified these very rare self-renewing cells that are resistant to standard therapies. We can identify and measure these cells many months before leukaemia develops. As such, we will use this mouse model to understand how these cells self-renew and how they can be killed
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Curing blood cancers: rapid translation from target to drug to clinic
  • 批准号:
    nhmrc : 1139466
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $47.83万
  • 财政年份:
    2018
  • 负责人:
    A/Pr David Curtis
  • 依托单位:
Curing blood cancers: rapid translation from target to drug to clinic
  • 批准号:
    nhmrc : GNT1139466
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $64.02万
  • 财政年份:
    2018
  • 负责人:
    A/Pr David Curtis
  • 依托单位:
Centre for Blood Transplant and Cell Therapy
  • 批准号:
    nhmrc : GNT1135107
  • 项目类别:
    Centres of Research Excellence
  • 资助金额:
    $250.0万
  • 财政年份:
    2017
  • 负责人:
    A/Pr David Curtis
  • 依托单位:
Centre for Blood Transplant and Cell Therapy
  • 批准号:
    nhmrc : 1135107
  • 项目类别:
    Centres of Research Excellence
  • 资助金额:
    $168.96万
  • 财政年份:
    2017
  • 负责人:
    A/Pr David Curtis
  • 依托单位:
海外基金