Safety of Hendra virus anti-G glycoprotein monoclonal antibody in humans
Safety of Hendra virus anti-G glycoprotein monoclonal antibody in humans
批准号:
nhmrc : 1041833
负责人:
A/Pr E Geoffrey Playford
金额:
$26.67万
依托单位国家:
澳大利亚
项目类别:
NHMRC Strategic Awards
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2013-12-31
中文摘要
亨德拉病毒感染是一种严重的,往往是致命的疾病。亨德拉感染没有治愈方法,现有的治疗方法无效。最近,一种人单克隆抗体在保护动物免受疾病发展方面显示出巨大的希望。该项目旨在进行临床前安全性测试和I期临床试验,以确定该抗体的安全性,使其可用于预防暴露于该疾病的人类的亨德拉感染。
英文摘要
Hendra virus infection in humans is a serious, and often fatal, disease. No cure exists for Hendra infection and existing treatments are ineffective. Recently, a human monoclonal antibody has shown great promise in protecting animals from developing the disease. This project aims to perform preclinical safety testing and a Phase I clinical trial to establish the safety profile of this antibody such that it can be used to prevent Hendra infection in humans exposed to the disease.
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