Architecture of the Hendra virus nucleocapsid and implications for replication

亨德拉病毒核衣壳的结构及其对复制的影响

• 批准号: nhmrc : GNT1085058
• 负责人: A/Pr Fasseli Coulibaly
• 金额: $ 22.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/architecture-hendra-virus-implications-replication/1345601
• 关键词: Architecture; Hendra; virus; nucleocapsid; implications

Hendra virus causes sporadic fatal outbreaks in horses, which may result in human deaths through direct contact with infected animals. The unanticipated surge of Hendra cases since mid-2011, the broad host range of the virus and the discovery of other related viruses worldwide highlight the epidemic potential of hendra-related paramyxoviruses. To improve our preparedness against paramyxoviruses, this Project aims at determining the structure of the viral replication machinery.

亨德拉病毒在马中引起散发的致命疫情，可通过直接接触受感染的动物导致人类死亡。自2011年年中以来亨德拉病毒病例的意外激增、该病毒广泛的宿主范围以及在世界范围内发现的其他相关病毒，突出了亨德拉病毒相关副粘病毒的流行潜力。为了提高我们对副粘病毒的防范能力，本项目旨在确定病毒复制机制的结构。