Novel mechanisms controlling signaling by adenosine monophosphate-activated protein kinase, central regulator of energy homeostasis

久坐的生活方式和高能量食物的消费导致肥胖相关代谢性疾病的发病率急剧上升，如2型糖尿病和心血管疾病，给澳大利亚经济带来了巨大的经济和医疗负担。治疗这些疾病的一个有吸引力的药物靶点是AMP激活的蛋白激酶(AMPK)，它既是细胞燃料计，也是全身新陈代谢的协调者。在圣文森特研究所最近取得的突破的基础上，该项目将对控制AMPK的新机制进行创新研究。这些发现将极大地增加我们对AMPK通过细胞过程调节的理解，并有助于设计更有效的AMPK药物。

Sedentary lifestyles and consumption of high energy foods have led to dramatic increases in the incidence of obesity-related metabolic diseases such as type 2 diabetes and cardiovascular disease, placing enormous financial and medical burden on the Australian economy. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK), which functions as both a cellular fuel gauge and co-ordinator of whole-body metabolism. Building on recent breakthroughs made at St. Vincent's Institute, this project will produce innovative research into novel mechanisms that control AMPK. These discoveries will greatly increase our understanding of AMPK regulation by cellular processes, and aid the design of more effective AMPK drugs.