Sedation Practice in Intensive Care Evaluation (SPICE) Randomised Controlled Trial.

几乎每个重症监护病人都需要镇静药物以获得安慰和提供挽救生命的治疗。然而，镇静会引起昏迷、谵妄和躁动等副作用。目前还没有高水平的证据来帮助医生决定选择哪种镇静剂以及最好的给药方式。SPICE试验将测试一种名为“早期目标导向镇静”的新方法，该方法基于一种替代镇静剂，以观察它是否能提供更安全、更有针对性的轻度镇静，并减少谵妄。

Almost every patient in intensive care needs sedating drugs for comfort and provision of life-saving treatment. However, sedation causes side effects including coma, delirium and agitation. There is no high-level evidence to help doctors decide which sedatives to choose and the best way to administer them. The SPICE trial will test a new approach called Early Goal-Directed Sedation based on an alternative sedative agent to see whether it delivers safer, targeted light sedation with less delirium.