Selective targeting of apoptotic pathways for therapy

所有动物的细胞都有自杀的能力。当细胞死亡的这一自然过程失灵时，就会出现癌症等疾病。针对细胞死亡机制关键组件的新型抗癌药物在一些患者身上显示出希望，但并不是全部。我们的目的是确定靶向其他细胞死亡成分是否可能是一种更有效的方法。我们还将开发新的化学物质，有朝一日可以将这种策略应用于临床。

The cells of all animals possess the ability to commit suicide. When this natural process of cell death is dysfunctional, diseases such as cancer arise. New anti-cancer drugs aimed at targeting key components of the cell death machinery are showing promise in some patients, but not all. Our aim is to determine whether targeting other cell death components could be a more effective approach. We will also develop new chemicals that could one day allow such strategies to be applied in the clinic.