A single molecule resolution approach to decipher the transcriptional regulation of endothelial cell fate

尽管它在健康和疾病中发挥着不可或缺的作用，但人们对支撑功能性淋巴管系统的分子基础知之甚少。这项研究项目将通过探索称为转录因子的蛋白质如何指导淋巴特异性遗传程序来解决我们知识中的这一空白。这项研究的发现有望为淋巴管疾病开辟新的治疗途径，包括肿瘤转移和水肿。

Despite its integral function in health and disease, little is known about the molecular basis that underpin a functional lymphatic vasculature. This research project will address this gap in our knowledge by exploring how protein known as transcription factors instruct a lymphatic specific genetic program. Discoveries from this research is expected to open up new therapeutic avenues for lymphatic vascular disorders which include tumour metastasis and lymphedema.