New chemoselective peptide heterodimerization and cyclization reactions for the development of novel PET radiopharmaceuticals

正电子发射断层扫描(PET)是一种强大的诊断工具，可用于检测和跟踪许多疾病，包括癌症、心脏问题和神经疾病。该程序需要在正电子发射计算机断层扫描之前给药放射性药物，并需要用于检测特定医疗问题的新型放射性药物，以充分利用这一新的诊断工具。在不同的医疗条件下表达的多肽激素受体对于开发新的、更具特异性的放射性药物具有特别的兴趣。本研究计划的目的是开发替代的合成方法来合成各种新的多肽衍生物，这些新的多肽衍生物随后可以用作改进的示踪剂，

Positron emission tomography (PET) is a powerful diagnostic tool for the detection and follow-up of many medical conditions including cancer, heart problems and neurological disorders. The procedure requires the administration of a radiopharmaceutical prior to the PET scan and novel radiopharmaceuticals for the detection of specific medical problems are required to fully exploit this novel diagnostic tool. Peptide hormone receptors expressed in different medical conditions are of particular interest for the development of new, more specific radiopharmaceuticals. The object of this research program is to develop alternative synthetic approaches for the synthesis of a variety of novel peptide derivatives that can subsequently serve as tracers for improved,