Response of red blood cells to desiccation and dry storage

有效保存和长期储存技术的发展是新兴细胞技术成功临床和商业应用的关键要求。由于组织工程、细胞和组织移植以及输血医学的疗效依赖于活细胞的天然和诱导特性，因此保持细胞和组织的功能活力仍然是修复医学面临的最重要挑战之一。干燥和干储存正在成为一种在环境温度下保存生物结构和/或生命系统功能的有吸引力的过程。细胞损伤与细胞对干燥和再水化过程中发生的许多物理和化学变化的反应的性质和动力学有关。在过去的二十年里，人们对自然系统（如昆虫、植物和线虫）对干燥的反应以及导致自然耐干燥的分子策略的理解取得了巨大进展。最近，人们对扩大对无水生物（无水生命）生物的研究感兴趣，包括对干燥敏感的哺乳动物细胞。

The development of effective preservation and long-term storage techniques is a critical requirement for the successful clinical and commercial application of emerging cell-based technologies. With the efficacy of tissue engineering, cell and tissue transplantation, and transfusion medicine dependent on the native and induced characteristics of living cells, preserving the functional viability of cells and tissues remains one of the most important challenges facing reparative medicine. Desiccation and dry storage is emerging as an attractive process for preserving the biological structure and/or function of living systems at ambient temperatures. Cell injury is related to the nature and the kinetics of the cellular response to the numerous physical and chemical changes that occur during drying and rehydration. Over the past twenty years, enormous progress has been made understanding the response of nature systems (for example insects, plants, and nematodes) to desiccation and the molecular strategies that are responsible for nature desiccation-tolerance. Recently there has been an interest in extending studies on anhydrobiotic (life without water) organisms to include desiccation-sensitive mammalian cells.