Somatic gene trapping in Schistosoma mansoni _ the key to functional analysis

血吸虫在76个国家流行，全世界有3亿人感染。控制主要依靠吡喹酮药物。然而，它的广泛使用引起了人们对耐药性产生的担忧。在这项研究中，我们将使用ñgene trap vectorsî将插入突变引入血吸虫基因组。这将有助于了解寄生虫使用的生化途径中基因的功能和重要性，并确定药物和疫苗开发的有效靶点。

Blood flukes are endemic in 76 countries and infect 300 million people worldwide. Control largely relies on the drug praziquantel. However, its wide scale use has led to concerns that drug resistance will develop. In this study we will use ñgene trap vectorsî to introduce insertional mutations into the schistosome genome. This will help to understand the function and importance of genes in biochemical pathways used by the parasite and to define effective targets for drug and vaccine development.