Spinal mechanism underlying arthritic joint pain

虽然慢性疼痛是一个严重的临床问题，但缓解它的治疗在很大程度上是失败的，部分原因是它们没有针对疼痛的具体来源进行量身定做。这项建议侧重于类风湿性关节炎，这是一种常见的、不可治愈的慢性疼痛来源。这项研究将调查脊髓神经细胞的特定变化如何导致慢性关节炎疼痛。这一结果将有助于确定治疗类风湿性关节炎慢性疼痛的新靶点。

Although chronic pain is a serious clinical problem, treatments for its alleviation have largely failed, in part because they have not been tailored to the specific origin of the pain. This proposal focuses on rheumatoid arthritis, a common and incurrable source of chronic pain. This study will investigate how specific changes in spinal cord nerve cells contribute to chronic arthritic pain. The outcomes will help identify new targets to treat chronic pain in rheumatoid arthritis.