Stem Cells as a symptom- and strUcture-modifying Treatment for knee OsteoaRthritis- the SCUlpTOR trial.

膝骨关节炎（OA）是残疾的主要来源，没有已知的治疗方法。为了弥补这一差距，需要安全有效的治疗方法来减轻症状并减缓结构性疾病的进展。虽然到目前为止还没有疾病调节剂被批准，但干细胞在这方面具有生物学潜力。与安慰剂相比，该试验将评估干细胞注射在减轻膝关节OA疼痛和减缓疾病进展方面的疗效。

Knee osteoarthritis (OA) is a major source of disability with no known cure. In order to address this gap, safe and effective treatments that reduce symptoms AND slow structural disease progression are needed. Whilst no disease-modifying agent has been approved to date, stem cells have biologic potential in this context. This trial will evaluate the efficacy of stem cell injections for reducing pain and slowing disease progression in knee OA compared to placebo.