Structural characterisation function analyses of type I interferon-receptor interactions

干扰素是机体对感染性和炎症性疾病以及癌症反应的重要组成部分。为了设计最佳的治疗方法来调节干扰素的活性，我们需要明确了解干扰素如何与靶细胞上的受体结合并激活其功能。该项目将利用X射线晶体学和同步加速器来表征细胞、小鼠和分子中的这些相互作用，以解决结构问题并促进知情的药物设计。

The interferons are an essential component of the body's response to infectious and inflammatory disease and cancer. In order to design the best therapeutic approaches to modulate interferon activity, we need a defined understanding of how IFN binds to its receptor on target cells and activates its functions. This project will characterize these interactions in cells, mice and molecules with x-ray crystallography and the synchrotron to solve the structure and facilitate informed drug design.