Charting the brain's wiring over the human lifespan

该项目旨在通过利用最先进的扩散磁共振成像(扩散磁共振)数据的标准建模方法，制作一个人类寿命范围内的大脑连接的大规模模型。该项目希望对健康个体的大脑连接如何随着年龄的变化产生新的理解。该项目的预期结果包括健康大脑连接的参考图，以及在扩散磁共振数据协调方法方面的重大进展。这将为先进的弥散磁共振成像方法的翻译提供显著的好处，因为脑连接的标准图表将被广泛使用。这可能对解释未来的个人弥散磁共振扫描具有广泛的意义。

This project aims to produce a large-scale model of brain wiring over the human lifespan by utilising normative modelling approaches on state-of-the-art diffusion magnetic resonance imaging (diffusion MRI) data. This project expects to generate new understanding of how the brain's connections change with age in healthy individuals. Expected outcomes of this project include a reference chart for healthy brain wiring, and major advances in diffusion MRI data harmonisation approaches. This should provide significant benefits for the translation of advanced diffusion MRI methods, as normative charts for brain wiring will be made broadly available. This could have broad implications for interpreting individual diffusion MRI scans in future.