A structural understanding of calcitonin gene-related peptide and adrenomedullin function

降钙素家族受体是生理上重要的受体，在骨质疏松症、偏头痛和心血管疾病的治疗中有重要作用。由于缺乏对这些GPCR如何被激活的机制的理解，靶向这些受体的治疗开发仍然具有挑战性。该提案将在分子水平上探索降钙素家族受体的结构和功能，从而改进新型治疗方法的发现和开发。

The calcitonin-family receptor are physiologically important receptors that have been implicated in treatment of osteoporosis, migraine and cardiovascular diseases. Therapeutic development targeting at these receptors remains challenging due to lack of mechanistic understanding in how these GPCRs are activated. This proposal will explore the structure and function of the calcitonin-family receptors at a molecular level, enabling improved discovery and development of novel therapeutics.