Structure and function of receptors for IgG (FcgammaR)

我们正在研究炎症性白色血细胞中最重要的受体家族之一，即所谓的Fc受体。这些对于保持对感染的抵抗力至关重要。不幸的是，它们也有助于引起主要炎性疾病，包括关节炎，狼疮和出血性疾病的组织损伤。我们对Fc受体如何触发炎症的研究将为开发治疗慢性炎症的新药和策略提供基础。

We are studying one of the most important receptor families of inflammatory white blood cells, so called Fc receptors. These are crucially important in maintaining resistance to infection. Unfortunately they are also instrumental in causing tissue damage in major inflammatory diseases including arthritis, lupus and bleeding disorders. Our studies of how Fc receptors trigger inflammation will provide the basis for the development of new drugs and strategies to treat chronic inflammation.