Structure and Function of Receptors for IgG (FcgammaR)

该研究项目试图了解抵抗感染性疾病的最重要机制之一，以及诱导自身免疫性疾病中破坏性炎症的最重要机制之一。这些研究将确定血液中的蛋白质抗体，抗体是如何通过Fc受体结合到白色血细胞表面的，Fc受体激活这些白色血细胞。在正常情况下，该系统提供对感染的抵抗力，但涉及一些最衰弱的疾病，包括过敏、称为血小板减少症的出血性疾病、血管炎症、血管炎以及类风湿性关节炎。该项目的成功完成将带来知识，从而能够开发更有效和高度特异性的治疗方法来治疗疾病，并更好地了解免疫系统的功能。

This reasearch project is attempting to understand one of the most important mechanisms of resistance to infectious disease and one of the most important mechanisms of induction of destructive inflammation in autoimmune disease. These studies will define how blood proteins called antibodies, antibodies bind to the surface of white blood cells via proteins called Fc receptors that activate these white blood cells. Under normal circumstances this system provides resistance to infection but is involved in some of the most debilitating diseases, including allergies, bleeding disorders called thrombocytopoenias, inflammation of blood vessels, vasculitis, as well as aspects of rheumatoid arthritis. The successful conclusion of this project will result in knowledge that will enable the development of more effective and highly specific therapeutic approaches to the treatment of disease and a better understanding of the functioning of the immune system.