Synthetic lethality screen targeting a defective checkpoint in melanoma

所有癌症在调节正常细胞生长和分裂的机制上都有缺陷。这些缺陷为癌症提供了生长优势，但也可能是跟腱。在这个项目中，我们将针对在高比例的黑色素瘤中发现的有缺陷的控制机制进行研究。我们将识别当被抑制时与有缺陷的对照相结合的基因，以特异性地杀死有这种缺陷的肿瘤细胞。正常组织受到其完整的调节机制的保护。

All cancers have defects in the mechanisms that regulate normal cell growth and division. These defects provide a growth advantage for the cancer, but can also be an Achilles Heel. In this project we will investigate targeting a defective control mechanism we found in a high proportion of melanomas. We will identify genes that when inhibited combine with the defective control to specifically kill tumour cells with this defect. Normal tissue is protected by its intact regulatory mechanism.