Modelling the human nervous system with human pluripotent stem cells.

人类神经系统是迄今为止进化出的最复杂的结构之一。为了理解它在疾病状态下是如何发挥作用和功能失调的，破译它是如何发展产生各种神经元群，形成这个复杂的网络是至关重要的。人类干细胞为研究这一过程提供了宝贵的资源。该项目的目的是利用人类干细胞来研究构建神经系统的早期祖细胞类型是如何产生的，以及它们的神经元衍生物是如何形成连接和功能突触的。这些研究的结果是，我们将建立一个可用于研究发育性疾病过程的人类神经发生的细胞模型。

The human nervous system is one of the most complex structures evolved to date. In order to understand how it functions, and dysfunctions in a diseased state, it is fundamental to decipher how it develops to generate various neuronal populations that form this elaborate network. Human stem cells provide a valuable source to study such processes. The aim of this project is to use human stem cells to study how early progenitor cell types that structure the nervous system are generated and how their neuronal derivatives form connectivity and functional synapses. The outcome of these studies is that we will establish a cellular model of human neurogenesis that can be utilised to study developmental disease processes.