Targeted development of AMPK ?2-isoform allosteric activators

久坐不动的生活方式和高能量食物的消费导致与代谢失调有关的疾病的发病率急剧增加，例如2型糖尿病。治疗这些疾病的一个有吸引力的药物靶点是AMP激活的蛋白激酶(AMPK)，它的功能是细胞燃料指示器。我们发现了一种新药，它可以关键地激活代谢活跃器官中发现的AMPK形式。我们的目标是开发这种药物，以释放新的治疗机会。

Sedentary lifestyles and consumption of high energy foods has led to dramatic increases in the incidence of diseases associated with metabolic dysregulation e.g. type 2 diabetes. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as a cellular fuel gauge. We have discovered a new drug that crucially activates the form of AMPK found in metabolically active organs. We aim to develop this drug to unlock new therapeutic opportunity.