Targeted nanoparticles to deliver combinations of calcium channel inhibitors to prevent myelin damage during secondary degeneration after neurotrauma

中枢神经系统受损后，损伤会扩散到附近区域，导致患者的预后更差。我们将制造纳米粒子系统，直接向最脆弱的细胞提供有效的治疗，这对功能至关重要。我们将修改纳米粒子，使它们能够到达损伤部位，无论是在损伤后的早期，还是在较长一段时间后。然后，我们将测试纳米粒子系统，看看它们是否能有效地保持功能

Following injury to the central nervous system the damage spreads into nearby areas, leading to worse outcomes for the patient. We will generate nanoparticle systems to deliver effective therapies directly to the most vulnerable cells, critical for function. We will modify the nanoparticles so that they can get to the injury site, both early after injury, and after longer periods of time have elapsed. We will then test the nanoparticle systems to see if they are effective at preserving function