Targeting Eph receptors as anti-cancer therapy in malignant glioma.

恶性胶质瘤是最常见的脑癌，其特点是发病率和死亡率都很高。目前的治疗包括手术和辅助放化疗，但尽管得到了最好的治疗，这种疾病患者的前景却很糟糕。对胶质瘤生物学的了解日益加深，为改进治疗方法提供了前景。这项建议试图在人类恶性胶质瘤的动物模型中研究这种疾病的治疗靶点。

Malignant gliomas are the commonest form of brain cancer and are characterised by a high degree of morbidity and mortality. Present treatment involves surgery and adjuvant chemoradiotherapy but despite best care the outlook for patients with this disease is poor. The increasing understanding of the biology of glioma offers the prospect of improved therapies. This proposal seeks to investigate a therapy target in this disease in animal models of human malignant glioma.