Targeting the toxins of preeclampsia

先兆子痫是一种严重的妊娠疾病--胎盘向母亲的血液中释放毒素，使母亲的身体循环，损害她的器官。由于没有有效的治疗方法，临床医生被迫无论怀孕与否都要接生。尽管先兆子痫的两种毒素已经确定，但对它们的调控知之甚少。该项目旨在阐明这些毒素的调节，并设计能够防止它们在临床上释放的疗法。

Preeclampsia is a severe disease of pregnancy - the placenta releases toxins in to mum's bloodstream that circulate her body and damage her organs. As there are no efficacious treatments, clinicians are forced to deliver babies irrespective of gestation. Although the two toxins of preeclampsia have been identified, little is known about their regulation. This project aims to elucidate the regulation of these toxins and design therapeutics that can prevent their release in the clinic.