Targeting Toxoplasma gondii latent stages responsible for chronic disease

许多微生物病原体通过进入缓慢生长的休眠状态而对宿主免疫反应和药物产生耐药性。这些阶段通常是长期慢性感染的原因。我们将研究弓形虫休眠的分子基础，它感染了三分之一的人。这些研究将确定对休眠至关重要的代谢途径，以开发治疗长期复发性感染的新疗法。

Many microbial pathogens become resistant to host immune response and drugs by entering a slow-growing, dormant state. These stages are commonly responsible for long term, chronic infections. We will investigate the molecular basis of dormancy in Toxoplasma gondii, which infects one in three people. These studies will identify metabolic pathways that are essential for dormancy with the view of developing new therapies for treating long term, recurrent infections.