Therapeutic potential of inhibiting Eph/ephrin signalling to repair the vascular endothelium in septic shock

感染性休克是一种危及生命的疾病，通常由血液中的细菌感染引起。在澳大利亚，每年有超过5000人死于脓毒症，其中包括500名儿童。在世界范围内，它是导致儿童死亡的最重要原因。脓毒症与液体和蛋白质通过血管衬里的细胞泄漏有关。该项目将开发和测试一种治疗脓毒症的新方法，其重点是通过阻断Eph/Ephin蛋白来减少这种渗漏。

Septic shock is a life-threatening condition usually caused by bacterial infection in the bloodstream. More than 5000 people, including 500 children, die from sepsis each year in Australia. Worldwide, it is the most significant cause of death in children. Sepsis is associated with leakage of fluid and proteins through the cells lining the blood vessels. This project will develop and test a novel treatment for sepsis which focuses on reducing this leakage by blocking the Eph/ephrin proteins.