Role of tuberin in mitotic progression

分裂成两个子细胞是发生在许多细胞种群的整个生命过程中的事件，涉及DNA的成功复制，随后是细胞分裂或胞质分裂。至关重要的是，这些事件以正确的顺序发生，没有错误，并且细胞在新的子细胞形成期间监测其大小和能量需求。对这些事件的协调和监测依赖于一种叫做细胞周期蛋白的调节蛋白和一种叫做细胞周期蛋白依赖蛋白S的催化蛋白家族。细胞周期蛋白和细胞周期蛋白依赖蛋白形成一种复合体，进而触发推动细胞通过这些细胞生长和分裂阶段的所有事件。这些重要复合体的形成和激活依赖于许多层的调节，其中大部分仍有待解决。这项研究的重点是确定这些复合体是如何调节的，以启动细胞分裂的开始。重要的是，我们的实验室有令人兴奋的数据，将监测营养和生长因子含量的蛋白质与细胞分裂联系起来。我们认为，这些数据反映了一个新的检查点，这对于维持适当的增长控制是必不可少的。

Division into two daughter cells is an event that occurs throughout life in many cell populations and involves the successful duplication of the DNA followed by cell division or cytokinesis. It is essential that these events occur in the correct order, without error and that the cell monitors its size and energy requirements during the formation of a new daughter cell. Coordination and monitoring over these events depends on regulatory proteins called cyclins and a family of catalytic proteins called the cyclin dependent kinases (CDK)s. Cyclin and CDK proteins form a complex that in turn trigger all of the events required to move the cell through these phases of cell growth and division. Formation and activation of these important complexes relies on many layers of regulation, much of which still remains to be resolved. This research program focuses on determining how these complexes are regulated to initiate the onset of cell division. Importantly, our lab has exciting data linking proteins known to monitor nutrient and growth factor content with cell division. We propose that this data reflects a novel checkpoint which is essential for maintaining proper growth control.