A Transmission-Blocking Vaccine To Prevent Toxoplasmosis

弓形虫引起一种全球重要的人畜共患疾病。它由猫传播，并通过受感染的肉类和受污染的水进入我们的食物链。我们使用了一条独特的功能基因组学管道来发现对猫体内弓形虫繁殖至关重要的蛋白质。我们现在将测试这些蛋白质的组合来免疫猫，并证明我们可以开发出一种疫苗，阻止这种高度重要的寄生虫病的传播。

Toxoplasma gondii causes a globally important zoonotic disease. It is transmitted by cats, and finds its way into our food chain via infected meat and contaminated water. We have used a unique functional genomics pipeline to discover proteins crucial for reproduction of Toxoplasma in the cat. We will now test combinations of these proteins to immunise cats and prove that we can develop a vaccine that blocks transmission of this highly significant parasitic disease.