权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Field trial and modeling of transmission blocking vaccine to prevent Lyme disease

预防莱姆病的传播阻断疫苗的现场试验和建模

基本信息

批准号：
10636945
负责人：
Maria Gomes-Solecki
金额：
$ 67.43万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-19 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10636945
关键词：
Adult Affect Antibodies Area Bayesian Modeling Black-legged Tick Blood Borrelia Borrelia burgdorferi Borrelia burgdorferi Group Canis familiaris Clinical Commercial grade Contracts Data Diagnosis Disease Ecosystem Endemic Diseases Environmental Exposure Excision Exposure to Funding Geographic Locations Geography Goals Habitats Health Human Immunize Incidence Infection Ingestion Intervention Ixodes Lyme Disease Lyme Disease Vaccines Modeling Morbidity - disease rate Mus New York North America Nymph Oral OspA protein Persons Population Prevalence Prevention Measures Proxy Public Health Publishing Recommendation Risk Risk Factors Seroprevalences Statistical Models Testing Tick Infestations Ticks United States Vaccination Vaccines Vector-transmitted infectious disease Work cohort data modeling disorder risk enzootic experimental study exposed human population exposure reduction interventions field study forest high risk human disease innovation knowledge translation predictive modeling prevent tick feeding tick transmission tool transmission process transmission-blocking vaccine vaccine distribution vaccine trial vaccinology vector tick

项目摘要

Summary Estimates from the CDC indicate that over 300,000 people are diagnosed each year with LD. Ecological approaches to decrease B. burgdorferi burden in Ixodes ticks, and transmission to other hosts, are highly desired tools for use instead of the current `check for ticks' approach. It is well established that after a vertebrate host is immunized with B. burgdorferi' OspA they produce antibody that, upon bloodmeal ingestion by a feeding tick, kills B. burgdorferi within that tick. These are known as transmission-blocking vaccines (TBV). These tools, including TBV, have not been proven to decrease B. burgdorferi exposure in critical intermediate incidental host(s). In North America, both humans and dogs are incidental hosts of B. burgdorferi. We and others have demonstrated that dogs can serve as stand-in/proxies for human exposure to infected ticks. Hunting dogs are a robust model for this trial because they serve both as a proxy of an active outdoors incidental host (like people at high-risk of contracting LD) and are a conduit of ticks into domestic habitats, increasing human exposure. The goal of this work is to demonstrate that a commercial-grade reservoir targeted TBV alters B. burgdorferi infection prevalence in questing ticks, in endemic areas (PA and MD) geographically distinct from the first field trial (NY). To show proof-of-principle for an ecological disruption of Borrelia transmission, we propose to: 1) establish the efficacy of a commercial-grade reservoir targeted transmission blocking vaccine (TBV) in reducing prevalence of B. burgdorferi in the tick vector and how it affects clinical disease in incidental hosts (dogs) in a five-year field study 2) Use a Bayesian hierarchical statistical model to estimate how TBV treatment of infected ecosystems will alter human B. burgdorferi exposure. These proposed studies are highly significant to public health as a field trial demonstration of a TBV that disrupts the enzootic transmission cycle of B. burgdorferi to incidental hosts. Furthermore, demonstration of reduced human (incidental host) Lyme disease will be performed through a stochastic Bayesian model that will provide critical evidence for a new tool to decrease environmental exposure to Lyme disease. This work innovates as a demonstration of an efficacious, easily distributable and inexpensive TBV that reduces B. burgdorferi prevalence in nymphal and adult ticks, as well as B. burgdorferi transmission from ticks to incidental hosts. Reduction of transmission of B. burgdorferi to incidental hosts as a result of TBV distribution will prove to be a paradigm-shifting strategy to reduce the burden of Lyme disease in veterinary and human populations. Findings from experiments proposed in this study will advance translational knowledge of B. burgdorferi vaccinology and will provide strong evidence regarding the possibility of TBV reducing the human health risk of exposure to Lyme disease across the United States.

总结

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Bayesian multivariate longitudinal model for immune responses to Leishmania: A tick-borne co-infection study.

利什曼原虫免疫反应的贝叶斯多变量纵向模型：蜱传共感染研究。

DOI：
10.1002/sim.9837
发表时间：
2023
期刊：
Statistics in medicine
影响因子：
2
作者：
Pabon-Rodriguez,FelixM;Brown,GrantD;Scorza,BreannaM;Petersen,ChristineA
通讯作者：
Petersen,ChristineA

Inclusion of environmentally themed search terms improves Elastic net regression nowcasts of regional Lyme disease rates.

DOI：
10.1371/journal.pone.0251165
发表时间：
2022
期刊：
PloS one
影响因子：
3.7
作者：
Kontowicz E;Brown G;Torner J;Carrel M;Baker KK;Petersen CA
通讯作者：
Petersen CA

Modulation of Macrophage Redox and Apoptotic Processes to Leishmania infantum during Coinfection with the Tick-Borne Bacteria Borrelia burgdorferi.

DOI：
10.3390/pathogens12091128
发表时间：
2023-09-04
期刊：
Pathogens (Basel, Switzerland)
影响因子：
0
作者：
Pessôa-Pereira D;Scorza BM;Cyndari KI;Beasley EA;Petersen CA
通讯作者：
Petersen CA

Deployment of a Reservoir-Targeted Vaccine Against Borrelia burgdorferi Reduces the Prevalence of Babesia microti Coinfection in Ixodes scapularis Ticks.

部署针对伯氏疏螺旋体的针对水库的疫苗可降低肩胛硬蜱中巴贝斯虫混合感染的患病率。

DOI：
10.1093/infdis/jiac462
发表时间：
2023
期刊：
The Journal of infectious diseases
影响因子：
0
作者：
Vannier,Edouard;Richer,LucianaM;Dinh,DuyM;Brisson,Dustin;Ostfeld,RichardS;Gomes-Solecki,Maria
通讯作者：
Gomes-Solecki,Maria