Tumour induced innate immune responses that control breast cancer metastases

乳腺癌扩散到骨骼的机制在很大程度上是未知的。我们发现，肿瘤细胞和免疫系统之间存在串扰，以诱导抗肿瘤免疫反应。通过减少已知的激活免疫反应的蛋白质(I型干扰素)的释放，肿瘤细胞可以躲避这种反应，并扩散到骨骼等组织。我们的目标是确定I型干扰素激活的免疫反应，以及这些途径的恢复是否可以阻止乳腺癌扩散到骨骼。

The mechanisms of breast cancer spread to bone are largely unknown. We have found that cross-talk between tumour cells and the immune system exists to induce anti-tumour immune responses. By decreasing the release of proteins known to activate immune responses (type I interferons), tumour cells can hide from such responses and spread to tissues such as bone. We aim to identify the immune responses activated by type I IFN and if restoration of these pathways can block breast cancer spread to bone.