Uncoupled Research Fellowship

我是一名神经学家，运用解剖学、生物化学、药理学、遗传学和行为分析的策略，研究新发现的神经肽及其同源受体在哺乳动物大脑中的生理和可能的病理作用。我最近的研究重点是2002年在HFI上发现的高度保守、含量丰富的多肽--松弛蛋白-3。到目前为止的研究表明，松弛素-3是节律性大脑活动(Theta)和空间记忆的强大调节器，并改变进食、体重和唤醒。大脑中的松弛素-3水平也会在急性压力下被强烈激活。在未来，我的目标是进一步阐明松弛蛋白-3系统在正常生理和代谢和/或精神疾病中的作用。

I am a neuroscientist employing strategies of anatomy, biochemistry, pharmacology, genetics and behavioural analysis to examine the physiological and possible pathological roles of newly discovered neuropeptides and their cognate receptors in mammalian brain. My recent research has focused on the highly-conserved, abundant peptide, relaxin-3 that was discovered at the HFI in 2002. Studies so far have revealed that relaxin-3 is a powerful modulator of rhythmic brain activity (theta) and spatial memory, and alters feeding, body weight and arousal. Relaxin-3 levels in brain are also strongly activated by acute stress. In the future, I aim to elucidate further the role of relaxin-3 systems in normal physiology and metabolic and-or psychiatric diseases.