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Using reconsolidation to understand the structure and molecular underpinning of memory - Steacie Supplement

Using reconsolidation to understand the structure and molecular underpinning of memory - Steacie Supplement
使用重新巩固来理解记忆的结构和分子基础 - Steacie Supplement
批准号:
373515-2009
负责人:
Nader, Karim
金额:
$16.76万
依托单位:
依托单位国家:
加拿大
项目类别:
EWR Steacie Fellowships - Supplement
财政年份:
2009
资助国家:
加拿大
项目状态:
已结题
起止时间:
2009-01-01 至 2010-12-31

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中文摘要
翻译
我们大脑拥有的最大能力之一是存储可以持续一生的记忆的能力。 记忆巩固理论认为,新的记忆最初进入一种不稳定的状态,称为短期记忆(STM),并通过产生新的蛋白质可以转化为长期记忆(LTM)。 这个过程被假定为对每个记忆只发生一次。最近,我证明了在提取之后,巩固的记忆需要在大脑中一种叫做杏仁核的结构中合成新的蛋白质,以使它们持续存在。 换句话说,当旧记忆被重新激活时,新记忆的储存机制似乎会被重演。 这种现象称为再固结。
英文摘要
One of the greatest capacities our brains possess is the ability to store memories that can last a lifetime. Memory consolidation theory posits that new memories initially enter a labile state called short term memory (STM) and through the production of new proteins can be transformed into long term memories (LTM). This process is posited to take place only once for each memory. Recently I have shown that following retrieval, consolidated memories require new proteins synthesis in a brain structure called the amygdala in order for them to persist. In other words, the mechanisms involved in the storage of new memories seem to be recapitulated when old memories are reactivated. This phenomenon is called reconsolidation.
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The Role of PKMzeta in Memory Destabilization and Reconsolidation
  • 批准号:
    RGPIN-2017-05140
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $5.68万
  • 财政年份:
    2021
  • 负责人:
    Nader, Karim
  • 依托单位:
The Role of PKMzeta in Memory Destabilization and Reconsolidation
  • 批准号:
    RGPIN-2017-05140
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.84万
  • 财政年份:
    2020
  • 负责人:
    Nader, Karim
  • 依托单位:
The Role of PKMzeta in Memory Destabilization and Reconsolidation
  • 批准号:
    RGPIN-2017-05140
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.84万
  • 财政年份:
    2019
  • 负责人:
    Nader, Karim
  • 依托单位:
The Role of PKMzeta in Memory Destabilization and Reconsolidation
  • 批准号:
    RGPIN-2017-05140
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.84万
  • 财政年份:
    2018
  • 负责人:
    Nader, Karim
  • 依托单位:
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