Understanding complex genomic and biochemical landscapes in human health microbiology

人们越来越认识到微生物在健康中所起的关键作用。我们肠道中的微生物产生的化学物质控制着我们的情绪、食物代谢和免疫系统功能。在本提案中，将使用微生物学、基因组学、质谱学和计算生物学等学科的前沿技术，首次揭示这些化学物质是如何以及为什么在对人类健康重要的复杂系统中由微生物产生的。

There is increasing awareness of the critical roles microbes play in health. The microbes in our gut produce chemicals that control everything from our moods, to food metabolism and immune system function. In this proposal leading-edge technologies from the disciplines of microbiology, genomics, mass-spectrometry and computational biology will be used to reveal for the first time how and why these chemicals are produced by microbes in complex systems that are important for human health.