Understanding the contribution of iron in traumatic brain injury

我们的研究小组发现了淀粉样前体蛋白（APP）在细胞铁平衡中的新作用，类似于另一种称为铜蓝蛋白（CP）的蛋白质。这两种蛋白质都是在大脑中发现的，它们将有害的铁转化为更安全的形式。任何一种蛋白质的破坏都会导致细胞死亡。我们的目的是确定APP和CP反应的失败可能对创伤性脑损伤的恢复不利。了解APP和CP的铁作用将导致治疗对抗创伤性损伤。

Our group has discovered a novel role of amyloid precursor protein (APP) in cellular iron balance similar to another protein called ceruloplasmin (CP). Both, prevalently found in the brain, convert a damaging iron variety into the safer form. Disruption in either protein leads to cell death. We aim to establish how failure in APP and CP response may be detrimental to traumatic brain injury recovery. Understanding the iron role of APP and CP will lead to therapeutics to counter traumatic injury.