Understanding and exploiting how different cell death pathways control intracellular infections

结核病、伤寒和流感继续夺去数百万人的生命。这些感染是由隐藏在宿主细胞内免疫系统的病原体引起的。我们的研究考察了允许免疫系统将这些病原体从细胞“藏身之处”驱逐出去的机制。这个项目将促进我们对免疫系统的基本了解，并将确定对抗这些全球杀手迫切需要的新疗法的目标。

Tuberculosis, typhoid fever and influenza continue to kill millions of people. These infections are caused by pathogens that hide from the immune system inside host cells. Our studies examine the mechanisms that allow the immune system to evict these pathogens from cellular 'hide-out'. This project will advance our basic understanding of the immune system and will identify targets for novel therapies that are desperately needed in fights against these global killers.