Understanding neuroinflammation in Alzheimer's Disease

该项目为研究参与AD进展的细胞信号机制开辟了一条新的思路，并确定靶向1型IFN信号的参与是否会影响AD的进化。治疗阿尔茨海默病显然需要新的和新颖的方法。重要的是，我们认为神经炎症在所有痴呆原因中都是常见的，靶向神经炎症途径比靶向主要致病途径具有更广泛的意义。

This project opens a new line of enquiry into the cellular signalling mechanisms involved in the progression of AD and establishes whether targeting the involvement of type-1 IFN signalling influences the evolution of AD. New and novel approaches are clearly required to treat AD. Importantly, we believe that neuroinflammation is common to all causes of dementia and targeting the neuroinflammatory pathways has much wider implications than targeting the primary causative pathway.