Understanding the post-transcriptional regulatory roles of the Hu family of RNA-binding proteins using HITS-CLIP

胚胎干细胞分化为神经元等分化状态需要细胞转录后基因调控的复杂变化。HU蛋白家族可能在这一调控中发挥关键作用，因为它们可以结合信息非翻译区，并改变这些信息最终是否构成蛋白质产品。在这个应用中，我们研究了HU蛋白在调节我们最近发现的特定mRNAs中的功能。

Differentiation of embryonic stem cells into differentiated states such as neurons requires complex changes in a cell's post-transcriptional gene regulation. The Hu family of proteins likely plays a critical role in this regulation, as they can bind message untranslated regions and change whether these messages ultimately make protein products or not. In this application we investigate the function of the Hu proteins in regulating specific mRNAs that we have recently identified.